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If this happens, the contrast agent may provoke seizures. LOCAs are the safer contrast agents in this respect. There is a link between osmolality of iodine contrast media and the risk of renal toxicity.

It also causes suppression of the adrenal cortex. Propofol is the most recently developed intravenous anaesthetic. The site of action of propofol is probably the GABA receptor.

EMLA is indicated prior to venepuncture and whenever pre-injection analgesia of the skin is required. This technique may be used by physiotherapists and radiographers under patient group directions. The anaesthetic is injected in or around the area requiring anaesthesia. The drug diffuses through the tissues and directly affects the nerve endings in the skin preventing conduction of nerve impulses. This method is commonly used when stitching wounds or during minor surgery limited to the skin thickness.

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The human brain is a complex organ made up of over as many glial cells. It is organized into systems, which sense, process and store, perceive and act on information received from outside and inside the body.



  • However, there are many people who have hyperuricaemia but do not suffer from gout.
  • This is traditionally undertaken by doctors and dentists.
  • It has been estimated that on average, for each prescription item older people receive, they use two additional non-prescription items.
  • This type of epilepsy is common in children.
  • Long-term treatment may be necessary to prevent relapse and chronic illness.
  • Because areas of the brain responsible for consciousness are the most sensitive it is possible to administer anaesthetics at concentrations that produce unconsciousness without seriously depressing the cardiovascular and respiratory centres or the heart muscle, but the margin of safety is narrow.
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The British Society for Rheumatology produces clinical guidelines for treatment of rheumatic diseases. Many of the same types of drugs are used to treat different rheumatic diseases.

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Fluorouracil is used to treat gastrointestinal and breast cancers, often together with synthetic folinates. Adverse effects of fluorouracil are less likely, but similar to methotrexate.

Authored by Dr. Izi Obokhare, MD


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