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  • PGDs should only be used where there is clear benefit for patients and by health care professionals with the necessary expertise and competence.
  • Anticipating that radiographers will gain independent prescribing responsibilities at some stage, then the following is suggested.
  • Some antihistamines, for example diphenhydramine and promethazine, are available for occasional insomnia; their prolonged duration of action may often lead to drowsiness the following day.
  • It is not known how widespread the use of PGDs is within the therapy community, but an unpublished national survey of radiotherapy service managers indicated that radiographers were involved in the administration of medicines using PGDs.
  • The rate of impulses from the baroreceptors decreases, the cardiovascular centre inhibits parasympathetic stimulation and increases sympathetic stimulation to the heart and blood vessels.
  • Adrenaline and noradrenaline are secreted from the adrenal medulla in response to sympathetic stimulation.
  • Newer drugs have been shown to interfere with GABA in other ways: by inhibiting GABA-transaminase, the enzyme responsible for inactivating GABA (vigabatrin and valproate) or by directly stimulating GABA receptors.

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